Translocator protein 18 kDa（ TSPO） is widely expressed in the mammalian nervous system and is commonly associated with processes such as neuroinflammation， neurodegeneration and neuroprotection. There is growing evidence suggests that the inflammatory response regulated by TSPO is closely related to depressive disorder. This paper summarizes the studies on TSPO and depressive disorder at home and abroad in recent years， with a view to providing clues and ideas for further research on the relationship between TSPO and depressive disorder and clinical application.