Parkinson's disease（ PD） is a chronic neurodegenerative disorder characterized by symptoms such as tremor， rigidity， bradykinesia， and balance impairment， in which the importance of the insulin signaling pathway in PD has received increasing attention. Patients with PD often have insulin resistance， which is closely related to the pathologic process of PD and the worsening of its symptoms. Antidiabetic drugs show potential neuroprotective effects in the treatment of PD due to their modulatory effects on insulin sensitivity. This paper describes the mechanism of insulin signaling pathway in PD， aiming to assess the prospect of antidiabetic drugs for PD.