Abstract:Objective 　To investigate the demographic and disease data of patients in psychiatricemergency who were not taking medicine. Methods 　Totals of 6 433 cases of non-medication patients whowere treated in department of emergency，Beijing Anding Hospital were included. According to the attack riskrating scale and the suicide risk factor rating scale，all patients were divided into attack group，suicide group，attack-suicide group and non-attack-non-suicide group. The demographic and disease data of each group were analyzed. Results　According to the demographic data，ratio of female to male was 3 628 to 2 805. Most patients were living in Beijing， Han nationality， between 21-30 years old. Based on disease data， most patients were withno inducement， introverted and with no family history. There were significant differences in gender (χ2=18.513)，residence (χ2=9.46)，partner (χ2=17.40)，relationship between parents (χ2=27.21)，job (χ2=11.078)，in-ducement (χ2=8.402)，character (χ2=11.059) and family history (χ2=9.129) between attack group and non-attack-non-suicide group (P ＜0.01). There were significant differences in gender (χ2=15.894)，relationshipbetween parents (χ2=6.594)，inducement (χ2=67.309)，character (χ2=4.309)，family history (χ2=5.719) and physical disease (χ2=32.779) between suicide group and non-attack-non-suicide group (P ＜0.05). Patientsdiagnosed with manic state were easier to show aggressive behaviour，while patients diagnosed with anxiety and depression were easier to have suicidal behavior (P ＜0.01). Conclusions　Most patients in psychiatric emer-gency department are women，aged 21-30 years old. Male patients who are living in Beijing，without partner，with bad relationship between parents，on duty，with inducement，extrovert，with family history of mental dis-eases and diagnosed with manic state are more likely to show aggressive behaviour. However female patients who are with bad relationship between parents，introvert，with inducement，with family history，with physical diseaseand diagnosed with anxiety and depression are more likely to have suicidal behavior.

Abstract:Objective 　To explore the correlation between dysfunctional attitudes and aggressivity，and the mediation effect of depression between dysfunctional attitudes and aggressivity in order to explore ways to protect mental health in college students. Methods　Totals of 1 050 college students in Shandong prov-ince were included to fill the questionnaire. The correlation between dysfunctional attitudes and aggressivity，and the mediation effect of depression between dysfunctional attitudes and aggressivity were analyzed. Results 　Physical aggression，verbal aggression，hostility，self-aggression，mandatory，seeking approval，cognitive of philosophy and depression were significantly different between male and female college students (P ＜0.05). Factors in an-ger showed significant differences between only child and not-only child (P＜0.05). Dysfunctional attitudes were related with aggressive factors (P ＜0.05)，except for cognitive of philosophy，verbal aggression and anger. De-pression showed partial mediation effect between dysfunctional attitudes and aggressivity，accounting for 16.32% of the total effect. Conclusions　Dysfunctional attitudes are associated with aggressivity. Depression shows par-tial mediation effect between dysfunctional attitudes and aggressivity.

Abstract:Objective 　To investigate the relationship between plasma CX3CL1 level and severityand prognosis of patients with acute cerebral infarction. Methods 　The clinical data and plasma of 139 acute cerebral infarction patients (case group) and 82 healthy controls (control group) were collected. Plasma CX3CL1 levels were determined by ELISA. Patients in case group were tested by NIHSS within 24 h after admission，and then tested by mRS after 3 months. Level of plasma CX3XL1 was compared between subgroups divided accord-ing to NIHSS score and mRS score in case group. Results 　Compared with control group，the level of plasmaCX3CL1 in case group were significantly lower (P=0.009). Logistic analysis showed that plasma CX3CL1 levelwas associated with the occurrence of acute cerebral infarction (OR=0.387，P=0.020). And there was a signifi-cant negative correlation between CRP and plasma CX3CL1 level (r=-0.232，P=0.003). There was a significant negative correlation between the plasma CX3CL1 level and the NIHSS score within 24 h after admission (r=-0.179，P=0.034). Compared with good outcome patients (mRS ＞2)，the poor outcome patients (mRS ≤2) had significant higher leukocyte count and CRP，and lower plasma CX3CL1 level (all P ＜0.05). And there was a significant negative correlation between the plasma CX3CL1 level and the mRS score after 3 months of acute ce-rebral infarction (r=-0.263，P=0.002). Logistic analysis showed that plasma CX3CL1 level was associated withthe prognosis of the patients (OR=0.087，P=0.004). Conclusions　The plasma CX3CL1 level of acute cerebral infarction patients was lower. And the plasma CX3CL1 level was significantly associated with the severity andprognosis of acute cerebral infarction patients.

Abstract:Objective 　To explore the characteristic of clinical interventions and treatment efficacy of acute schizophrenic inpatients with aggressive behaviors before admission. Methods 　Totals of 151 acute schizophrenic inpatients were recruited and divided into two groups (group A: patients with aggressive behaviors; group B: patients without aggressive behaviors) based on score of the Modified Overt Aggression Scale (MOAS). Disease information and clinical interventions were recorded using the self-made questionnaire. The aggressive behaviors occurred one week before the hospitalization，the agitation symptoms，the nurse risks，the severityand treatment efficacy of the subjects were evaluated using the Modified Overt Aggression Scale (MOAS)，thePositive and Negative Syndrome Scale Excited Component (PANSS-EC)，the scale of assessment on nurse risks and the Clinical Global Impression (CGI). Results　(1) Of 151 inpatients，74 cases had aggressive behaviorsbefore admission，and 77 cases didn’t. (2) Compared to inpatients in group B，the rate of inpatients in group A on previous violent/aggressive behavior and the proportion on no drug administration were all higher (P ＜0.05).The severity of disease was higher in group A (P ＜0.05). The scores of CGI-SI，PANSS-EC、BARS and MOAS，and the risk of aggression and rate of anti-attack care advice were also higher in group A (P ＜0.05). (3) All in-patients were prescribed by the second generation antipsychotics. The ratio of risperidone was 68.9%，followed by olanzapine (13.2%) and quetiapine (5.3%). The ratios of haloperidol intramuscular injection and safeguard re-straint usage in group A were more than those in group B (P ＜0.05). (4) There were no significant differences on the scores of CGT-SI，MOAS，PANSS-EC， diseases severity and the days of stay in hospital between two groups (P＞0.05). Conclusions 　The treatment efficacy of the inpatients with aggressive behaviors before admission is as same as that of inpatients without aggressive behaviors. The inpatients with aggressive behaviors have moreagitation symptoms and higher risk of aggression and flee. During hospitalization，the applications of haloperidol intramuscular injection and safeguard restraint in patients with aggressive behaviors were more frequently.

Abstract:Objective 　To explore the correlation between the blood-brain barrier dysfunction and clinical prognosis in patients with Guillain-Barre syndrome (GBS). Methods 　Totals of 78 patients with GBS in department of neurology were followed-up from January 2013 to June 2016. All patients were divided into two groups based on Hughes scale at 6 months：the good prognosis group (Hughes ＜3) and poor prognosis group (Hughes ≥3). Clinical and biochemical data，as well as immunotherapy were analyzed. Results　Between the good and poor prognosis groups，there were no significant differences in gender，age，onset season，proceedinginfection，pneumonia，mechanical ventilation，cerebrospinal fluid protein，immunoglobulin G，IgG-index，intrathecal IgG synthesis rate within 24 hours，injury of nerve axonal and immunotherapy (P ＞0.05). There were statistically significant differences in score of muscle strength on admission and albumin CSF/serum ratio(QALB) (χ2=11.73，8.01；P ＜0.05). Blood-brain barrier dysfunction was positively correlated with clinical poor prog-nosis (r=0.32，P ＜0.01). Conclusions 　The blood-brain barrier dysfunction in patients with GBS is associated with poor prognosis. Therefore，blood-brain barrier permeability may be used to predict the prognosis of patient with GBS.

Abstract:Objective 　To investigate the proper management of spinal subpial lipoma with-out dysraphisms. A new subset classification method was proposed for individual handling protocols.Methods 　We retrospectively reviewed five cases of patients diagnosed with subpial lipomas who received sur-gical treatment in Department of Neurosurgery，Beijing Jishuitan Hospital between January 2013 and December 2014. The patients’clinical histories and medical records were carefully examined，and radiological charac-teristics were periodically retrieved after surgery. The outcomes of these patients were also reviewed. The fivepatients were grouped into 2 groups based on MRI characteristics：simple type and invasive type. Results　All five patients had mild to moderate neurological impairment and underwent surgical treatment. In two patients of simple type，one was underwent total removal while the other underwent partial removal. And three patients of invasive type all underwent partial removal. Tumor resection was confirmed in postoperative MRI. All patientswere confirmed as lipoma by pathology. Patients of different types showed different imaging features and neuro-logical recovery. Patients of simple type were complicated with syringomyelia and were easy to probe intraoperative tumor border. Patients of invasive type had tumor with nerve tissue passing through and easy to be damaged duringexcision which could be comfirmed in postoperative pathology. All patients showed temporary neurological impairment after surgery. But patients of simple type had better prognosis and could return to preoperative neurological function in two years. Conclusions　The classification of simple and invasive type may be helpful in understanding spinal subpial lipoma without dysraphisms. The boundary between tumor and spinal cord could be generaly found inpatients of simple type，so the tumor may be completely removed. But invasive tumors are invasive growth. Any attempt to remove the tumor may lead to further damage to the spinal cord function. Decompression surgery may be the best choice for invasive tumors.

Abstract:Objective 　To understand the anxiety，depression and social support of gestational diabetes mellitus（GDM）women in perinatal nutrition clinic in Beijing. Methods 　In accordance with the representative method of stratified random sampling，extraction，comprehensive urban suburban hospital，a to-tal of 456 pregnant women with GDM who were diagnosed for the first time in perinatal nutrition clinic at 24-28 gestational weeks in January to August， 2016 were selected in this study for questionnaire survey. Survey includ-ed questionnaire on general information，Self-rating Anxiety Scale（SAS），Self-Rating Depression Scale（SDS）and Social Support Scale. The results were statistically analyzed. Results 　The SAS score of pregnant women with GDM was （57.12±4.61），SDS score was （59.62±4.38）. Anxiety and depression of GDM patients were negatively correlated with social support utilize degree，social support scores and subjective support （P＜0.05）. Elderly primi-para，pre-pregnancy BMI≥25kg/m2 ，higher education，adverse pregnancy，living in the city were risk factors of the occurrence of anxiety and depression in pregnant women with GDM. However，social support was a protective factor. And the social support of GDM pregnant women who lived in country was lower. Conclusions　Pregnant women with GDM are easy to be anxiety and depression. It is suggested that health education classes should be set up in peri-natal nutrition clinic to provide psychological guidance and strengthen social support to pay attention to mental health of pregnant women with GDM.

Abstract:Objective 　To evaluate the relationship among the course，efficacy and safety on Bailemian therapy for anxiety in patients with somatic disease. Methods 　We retrieved the China journal full-text database(CNKI)，Wanfang database，China’s outstanding master’s/doctoral dissertation database，VIP science and technology periodical database，Cochrane library，PubMed，EMBASE and Chinese academic conference papers，collected and selected related literatures published before Dec，2016 on Bailemian therapy for anxiety. The Cochrane Collaboration’s tool，Stata and RevMan software were used for data analysis. Results 　Twelve literatures including 1 060 patients (536 in treatment group， 524 in control group) were included. The combined RR(95%CI)were 1.33(1.21-1.45) for efficiency and 0.42(0.26-0.70) for adverse-event. The difference of HAMA betweenBailemian and the control group was significant ［SMD=-0.36(-0.65- -0.07)］. The merged RR(95%CI) of effi-ciency were 1.34(1.16-1.54)，1.24(1.07-1.45)，1.36(1.15-1.60)，1.50(1.06-2.13) respectively，for the treat-ment of 2 weeks，4 weeks，8 weeks and 12 weeks. The merged SMD(95%CI) were -0.96(-1.85- -0.06)，-0.28 (-0.70-0.14) and -0.75(-1.36- -0.13) for the treatment of 2 weeks，4 weeks and 8 weeks respectively. And the RR(95%CI) of adverse events in the course of 4 and 8 weeks were 0.25(0.09-0.69) and 0.41(0.19-0.91). Conclusions　Bailemian capsule is effective and safety to improve the symptoms of anxiety in patients with so-matic disease. The longer the courses is，the more significant of the efficacy on Bailemian therapy for anxiety is. It might be worth further popularizing in clinical use.

Abstract:Objective 　To investigate the mental health status of retired veterans in a hospital，analyze the causes and influencing factors of bad psychological status，and to propose a series of effective countermeasures. Methods 　A total of 380 retired cadres who lived in a certain hospital in Beijing from August 2015 to April 2016 were studied. The mental health status of these patients were tested by SCL-90 and compared according to different age and diseases status. Results 　There were various psychological problems of retiredveteran cadres in hospital. The retired cadres in elderly group showed significantly higher subscores of soma-tization，force，psychosis and and lower subscores of interpersonal relationship and paranoid ideation than norms (P＜0.05). Except for paranoid ideation and phobia factors，there were significant differences between the elderly and middle-aged group (P＜0.05) . There were significant differences in phobia factor and somatization factor between out-side hospitalized patients and non-hospitalized patients in elderly group (P＜0.05) . Conclusions　The retired vet-eran cadres in hospital have different degrees of psychological problems. Their mental health is related to age and illness. Therefore retired cadres need psychological diagnosis and corresponding treatment.

Abstract:Objective　To evaluate the effect and safety of different doses of alteplase on acuteischemic stroke (AIS) patients less than 70 years old. Methods 　From October 2012 to June 2016，184 AIS patients less than 70 years were randomly divided into standard dose group (n=93) and low dose group (n=91). 0.9 mg/kg and 0.6 mg/kg alteplase were given for intravenous thrombolysis respectively. The differences in themortality rate and modified Rankin Scale (mRS) were compared between two groups at 90 days after treatment.The incidence of symptomatic intracranial hemorrhage (SICH) and other adverse events were evaluated meantime. Results　Totals of 92 cases and 91 cases in two groups completed the study respectively. The mortality ratesof patients in two groups were 10.87% and 8.79% within 90 days after onset of the disease respectively. Therewas no significant difference between two groups (P ＞0.05). The death or neurological deterioration rate in 72 h after onset of the disease in two groups was 14.13% and 12.09% (P ＞0.05). There was no significant difference in mRS distribution between two groups (P ＞0.05). The incidence of SICH in two groups was 7.53% and 5.49% respectively (P＞ 0.05). The overall incidence of adverse events in two groups was 19.35% and 18.68% (P＞ 0.05).Conclusions　The thrombolytic effect of low-dose alteplase on non-elderly acute ischemic stroke patients iswell. The prognosis and risk of hemorrhagic transformation are comparable to the standard dose.

Abstract:Objective 　To investigate the current situation of neurosyphilis patients first-visitingin psychiatric clinic，and explore the outcome and prognosis of these patients. Methods 　Outpatients who had the positive result of RPR and were diagnosed as neurosyphilis were selected from January 2008 to Decem-ber 2015. All patients were followed up in 3 months，6 months and 12 months. Results　In these 76 patients，43 were male，33 were female. Up to 12 months follow-up survey，36 patients showed cognitive impairment，18 showed manic or depressive states，10 had hallucinations and delusions，9 showed improvement，2 werecured and one died. All 76 patients were treated with anti-psychotic drugs，antidepressants，antimanics or an-ti-anxiety drugs. 32 patients received anti-syphilis treatment，while 44 patients were not. So all patients weredivided into anti-syphilis treatment group and non-anti-syphilis treatment group. MMSE scores of patients in two groups were not significantly different (P ＞0.05). MMSE scores of patients in either group were significantly dif-ferent in 12 months follow-up survey with that at baseline (P ＜0.05). Conclusions　The effect of antipsychotics treatment and anti-syphilis treatment for neurosyphilis patients are not significant. Neurosyphilis patients havecognitive impairment.

Abstract:目的　通过对特发性快速眼球运动睡眠行为障碍（iRBD）患者认知脑区改变的探索，寻找其与帕金森病（PD）患者大脑形态改变的异同，为两者的联系提供依据。方法　对14 例iRBD 患者、12 例PD 患者及8 名健康人（CON 组）进行认知心理测评（复杂图形测试、临摹及回忆、符号-数字转换测试、连线测试、画钟测试、数字广度测验）及磁共振检查，采用基于体素形态学的研究技术进行分析。结果　iRBD 组及PD 组患者的数字符号转换测试、连线测验测试2 与CON 组之间的差异均有统计学意义（P ＜0.05），iRBD 组与PD 组间的差异无统计学意义（P ＞0.05）；与CON 组比较，iRBD 组与PD 组患者的右顶叶及左枕叶体积均缩小（P ＜0.05），但iRBD 组与PD 组间的差异无统计学意义（P ＞0.05）；PD 组右枕叶较CON 组体积减小（P ＜0.05）。结论　iRBD 患者及PD 患者均出现注意力及执行功能等认知能力下降，并且都出现右顶叶和枕叶萎缩，提示两者的认知损害存在相似的病理基础。

Abstract:抑郁症伴慢性疼痛已经成为影响公众健康的重要因素之一，流行病学研究发现66% 的抑郁症患者常伴有慢性疼痛，73.3% 慢性疼痛患者会诱发抑郁症。现围绕抑郁症伴慢性疼痛的神经递质、神经内分泌、神经炎症及肠道菌群失调的病理机制及药物治疗在这种共病中的作用进行综述，并对药物治疗在这些共病中未来研究的发展方向进行展望。

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Abstract:精神分裂症在人群中的发病率约1%，目前最有效的治疗方法为长期、甚至终身服用抗精神病药物控制症状。以奥氮平、利培酮等为代表的第二代抗精神病药物(SGA) 因其保留了第一代药物的抗精神病作用，却无或很少有锥体外系症状，而成为当今一线用药。然而，SGA 也有明显的不良反应，它们能够增加患者体重，从而导致肥胖症，而肥胖症又是糖尿病、心血管疾病的重要风险因素，因此，深入探究其引起肥胖症的机制对于未来研发新药来预防和治疗以肥胖症为代表的代谢综合征意义重大。现对近几年研究者们从不同的机制阐述SGA 引起的肥胖症的研究内容进行总结，旨在为科研工作者提供新的探究思路。

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