Abstract:This paper analyzes the current status and future direction of community mental health service， in the light of the development trend of the global community mental health service， and puts forward some suggestions for the future development of community mental health in China， so as to provide reference for community mental health administrators.

Abstract:Objective To test the reliability and validity of the Chinese version Psychiatric Anger Rating Scale（ PARS）. Methods With the consent of the original author， English version PARS was translated into Chinese. PARS contains 41 items. A total of 125 psychosis from Shanghai Mental Health Center were collected to evaluate with PARS. Cronbach's α was applied to measure internal consistency reliability， Guttman Split-Half to measure Split-Half reliability. The correlation coefficient between each item and total score was calculated. Exploratory factor was used to analyze and test the construct validity of PARS. Pearson correlation analysis was used to explore associated validity between PARS and Positive and Negative Symptom Scale （PANSS）. Results Cronbach's α was 0.89. Guttman Split-Half was 0.88. Correlation coefficient between each item and total score was from 0.19 to 0.72（ P＜0.05）. Exploratory factor analysis yielded 9 factors， accounting for 67% of the total variance. There was a significant correlation between PARS and item-G14 of the PANSS（ lack of anger control）（ r=0.54，P＜0.05）. Conclusions Chinese version PARS has a good reliability and validity， which can be used to study anger symptoms in Chinese psychotics.

Abstract:Objective To observe the effects of concurrent radiochemotherapy on peripheral blood T lymphocyte subsets in patients with glioma， so as to provide immunological indicators for the treatment of glioma. Methods A total of 150 patients with glioma admitted to the glioma department of Beijing Shijitan Hospital from January 2015 to December 2017 were recruited into the glioma group， and the other 150 healthy people who undertook health examination in the health examination center were assigned into the control group. The content of T lymphocyte subsets in peripheral blood of healthy control group and glioma patients before and after concurrent chemoradiotherapy were determined by fluorescence- activated cell sorter（ FACS）. Results The results showed that there was no statistical significance in the difference of CD3+ in peripheral blood of patients between the two groups before treatment（ P＞0.05）. with glioma was not statistically significant （P ＞ 0.05）. The mean CD4+ and CD4+/CD8+ were significantly lower than those in healthy controls. The mean CD8+ was significantly higher than the healthy control group. The difference was statistically significant（ P ＜ 0.05）. The mean CD3+， mean CD4+ and CD4+/CD8+ of glioma patients before concurrent chemoradiotherapy were significantly higher than those after concurrent chemoradiotherapy， and the difference was statistically significant（ P＜0.05）. The mean value of CD8+ was significantly increased after treatment， and the difference was statistically significant（ P＜0.05）. Conclusions The immune function of patients with glioma is decreased. The defection in immune function after concurrent chemoradiotherapy is more obvious. Peripheral blood T lymphocyte subsets can be used as an immunological reference index for clinical evaluation of glioma concurrent chemoradiotherapy.

Abstract:In order to further deepen the reform of the medical and health system and improve the ability of community mental health service， a mental health medical alliance was established in Chaoyang District with the integration of tertiary psychiatric hospital in Beijing and psychiatric hospitals and psychiatric department in general hospital in Chaoyang District. A psychiatric liaison consultation center was set up which condense the resources of the psychiatric experts in Beijing to provide high level professional technical support. Psychiatric departments are set up in all community medical institutions within the jurisdiction to provide convenient and accessible psychiatric services for patients and to promote the training of community mental health professionals.

Abstract:The implementation of community mental health special service project in Chaoyang District has effectively improved the capacity of community mental health services， promoted the construction of community mental health service team， and broadened the object and service mode of community mental health service.

Abstract:Peer support service for severe mental disorders is a low-cost， effective and multi-beneficiary rehabilitation method， which meets the needs of the development of mental illness service model. This article introduces the situation of peer support for patients with severe mental disorders in Chaoyang District community of Beijing， and explores ways to promote peer support at the community level.

Abstract:Objective To explore the molecular mechanism of alpha-asarone to affect learning and memory skills of lithium chloride pilocarpine induced Epileptic Rats. Methods SD rats were randomly divided into 3 groups： normal saline group， epilepsy group， and alpha-asarone group. Lithium chloride pilocarpine injection were applied to induce rat epilepsy models. The rats of the alpha-asarone group were given alphaasarone 28 days before modeling. Water maze was used to detect the spatial learning and memory ability of the SD rats. Western blot technique was used to detect the expressions of PI3K， Akt and mTOR proteins of hippocampus in lithium chloride pilocarpine induced epileptic rats．RT-PCR technique was used to detect the expressions of PI3K， Akt and mTOR mRNA of hippocampus in lithium chloride pilocarpine induced epileptic rats. Results Water maze test result showed that alpha-asarone can improve the spatial learning and memory ability of the SD rats. The expression of PI3K， Akt and mTOR proteins decreased obviously in epilepsy group compared with those in saline group（ P＜ 0.05）. The expressions of PI3K， Akt and mTOR proteins increased obviously in alpha-asarone group compared with those in epilepsy group（ P＜0.05）. The results of RT-PCR technique showed that the expressions of PI3K， p-Akt and mTOR mRNA decreased obviously in epilepsy group compared with those in saline group（ P＜0.05）， and the expressions of PI3K and p-Akt mRNA increased obviously in alpha-asarone group compared with those in epilepsy group（ P＜0.05）. Conclusions Alpha-asarone can improves learning and memory of lithium chloride pilocarpine induced epileptic rats， and the molecular mechanism maybe related to up-regulation of the expressions of PI3K， Akt and mTOR proteins and mRNA.

Abstract:Objective To explore the relationship between family environment， coping style and anxiety and depression， and the mediating mechanism of coping style in the process of family environment affecting anxiety and depression. Methods A total of 1 950 freshmen from a university in Daqing were investigated with Family Environment Scale and Simple Coping Style Questionnaire， Self-rating Anxiety Scale and Self-rating Depression Scale. Results Among 1 902 recycled questionnaires， there were 1 846 valid questionnaires， with an effective rate of 94.67%. In all the students， there were 471 male（ 24.15%） and 1 432 female（ 73.44%）. Compared with male， female freshmen scored higher in emotional expression， conflict， success， organization， control dimension and positive coping（ P＜0.05）. All dimensions of family environment were significantly correlated with coping styles， anxiety and depression scores（ P ＜ 0.01）. The influence of family environment on freshmen's anxiety and depression was partially mediated. Chi square freedom ratio （χ2/df） was 23.158 and 16.252； Goodness of fit index（ GFI） was 0.947 and 0.960； Adjusted goodness of fit index（ AGFI） was 0.893 and 0.921； Root mean square error approximation（ RMSEA） was 0.108 and 0.090. It is suggested that the fitting degree of the two models was ideal. Conclusions Family environment and coping style are significantly related to anxiety and depression. Family function can directly affect freshmen's anxiety and depression， and can also indirectly affect anxiety and depression through coping style. It is suggested that attention should be paid to the guidance and correction of college students' coping styles， which is of great significance to the psychological health of college students.

Abstract:Objective To investigate the effects of folic acid on elderly patients with chronic schizophrenia. Methods A total of 100 cases of elderly patients with chronic schizophrenia were divided into control group and study group by random number table method. Patients in the study group were given oral intervention of 10 mg/d folic acid. The results of hemoglobin， red blood cell count， blood homocysteine （Hcy）， folic acid level and Mini-mental State Examination（ MMSE） and Wisconsin Card Sorting Test（ WCST） were compared and analyzed before and after treatment. Results After folic acid intervention， compared with the control group， the level of folic acid in the study group increased， the Hcy level decreased， while the hemoglobin and red blood cell count increased. And the differences were statistically significant compared with those before treatment（ P＜0.05）. After treatment， the score of negative scale decreased and the number of completed classifications increased in the study group. The difference between the control group and the treatment group was statistically significant， but the difference of MMSE score was not statistically significant. Conclusions Folic acid adjuvant therapy for elderly patients with chronic schizophrenia can improve the physical symptoms such as anemia， and also can improve the negative symptoms and cognitive symptoms of patients to a certain extent.

Abstract:Objective To explore the relationship between posttraumatic stress disorder（ PTSD） stress symptoms and blood homocysteine， folic acid， and vitamin B12 metabolism. Methods From November 2016 to November 2017， officers and soldiers stationed in Xinjiang were divided into PTSD group（ n=27） and non-PTSD group（ n=39） according to the positive result of PTSD Checklist- Civilian Version（ PCL-C） and Diagnostic and the diagnostic criteria of Statistical Manual of Mental Disorder（ DSM-5）. The fasting plasma homocysteine， folic acid， vitamin B12 and some other hematological indexes in the two groups were analyzed. Results The levels of serum homocysteine， folic acid， vitamin B12， T3 and T4 were significantly different between the two groups. However， there was no statistical difference in TSH， LDL， HDL-C. Conclusions The plasma homocysteine is higher in PTSD patients， folic acid and vitamin B12 are lower.

Abstract:Objective To investigate the effects of olanzapine on serum vascular endothelial growth factor（ sVEGF） levels in first-episode schizophrenic patients and its relationship with clinical efficacy. Methods A total of 40 first-episode schizophrenic patients（ patients group） were enrolled in the study. They were treated with olanzapine only for 4 weeks. The psychiatric symptoms were estimated using the Positive and Negative Syndrome Scale（ PANSS）. sVEGF levels were determined in patients and 40 normal controls（ normal group） using enzyme linked immunosorbent assay（ ELISA）. Results Before treatment， the sVEGF levels in the patient group was（ 331.8±80.1） pg/ml， which were significantly lower than that in the normal group （506.1±211.5） pg/ml. The sVEGF level after taking drug was（ 475.7±128.5） pg/ml， which was higher than before， and the difference was statistically significant（ t=6.489，P ＜ 0.05）. However there was no significant difference when compared with the control group（ P＞ 0.05）. The PANSS score of the patients was lower than that of the patients before treatment， and PANSS reductive ratio was positively correlated with sVEGF changes （r=0.439， P=0.005）. Conclusions It is suggested that sVEGF may be an suitable biomarker for schizophrenia. Effective antipsychotic drugs can increase the sVEGF level and the change of sVEGF may be a correlation index of the antipsychotic drugs efficiency.

Abstract:Objective To explore the characteristics of stigma in Tibetan patients with firstepisode depression and compare with those of Chinese Han patients， and to analyze the relationship between personalities and stigma in Tibetan depressed patients. Methods A total of 60 Tibetan patients and 60 Chinese Han patients with first-episode depression were selected as subjects. The Link Stigma Scale and the Big Five Personality Scale were respectively used to investigate stigma of disease and personalities. Results In the Link stigma scale， the score of regression factor of Tibetan patients was higher than that of Chinese Han patients， which was（ 2.45±0.25） and（ 2.33±0.24） respectively（ t=-2.082，P＜0.05）. In the Big Five Personality Scale， the neuroticism of Tibetan patients was lower than that of Chinese Han patients， which was（ 3.16±0.51） and （3.79±0.64） respectively（ t=2.153，P＜ 0.05）. The score of extroverted factors of Tibetan patients was higher than that of Chinese Han patients， which was（ 2.78±0.63） and（ 2.22±0.68） respectively（ t=2.747，P＜0.05）. Among Tibetan patients， the score of openness factor of Big Five Personality Scale is negatively correlated with the score of Discrimination-perception Scale and Emotional Experience Scale（ r=-0.337，-0.311； P＜0.01）. While conscientiousness factor score was positively correlated with both（ r=0.404， 0.375；P＜0.01）. Neuroticism score was positively correlated with the score of Discrimination-perception Scale（ r=0.305，P＜0.01）. Conclusions Tibetan patients with first-episode depression have different stigma with Chinese Han people and are affected by personalities.

Abstract:Objective To detect the change of proliferation and further find out the survival state of vascular smooth muscle cells（ VSMCs） after knockdowned the expression of Notch 3 by RNA interference in different surroundings. Methods Ox-LDL and IGF-1 were applied to intervene normal VSMCs and Notch knockdowned VSMCs. Cell growth was observed under inverted microscope. Cell growth curve was detected by CCK-8. Results The growth curve of the ox-LDL control group was obviously higher than that of the ox-LDL positive group. During the first four days， the growth curve of ox-LDL control group， IGF-1 positive group and IGF-1 control group were higher than that of the other groups. This trend was more obvious in the fifth and sixth day. The proliferative rate was similar among the 3 groups. Conclusions For Notch 3 signal system， ox-LDL and IGF had different effects. When Notch 3 was inhibited， the proliferation of ox-LDL decreased. However， the proliferation promoting effect of IGF-1 on VSMCs remained.

Abstract:Objective To analyze the management and treatment situation for patients with severe mental disorders in Shaanxi Province in 2015， in order to provide references for government to formulate mental health policies and provide services for mental health professional institutions. Methods Descriptive method was used to analyze demographic characteristics， register， management and treatment situation of the patients with severe mental disorders admitted into the national information system of Shaanxi Province from August 1st， 2011 to December 31st， 2015. Results By the end of 2015， there were 126 120 patients registered， with the registered rate of 3.35‰. 115 993 patients were provided with follow-up services by primary health care staff， with the management rate of 91.97%. 70 378 patients were follow-up regularly， and the regular management rate was 55.8%. 61 270 patients were treated by taking antipsychotics， and the rate was 52.82%. 30 781 patients took medication regularly， and rate of regular taking medication was 26.54%. Conclusions The management and treatment of severe mental disorders in Shaanxi Province has been carried out and achieved some results， but the reported prevalence rate， standardized management rate and regular medication rate need to be further improved.

Abstract:The word "Hikikomori" was originated from Japan to describe a group of people who live in seclusion at home， away from their families， friends， not to go to school， not to work， and not to be employed. In recent years， other countries have also seen cases of "Hikikomori". This article reviews the related research from the perspective of the diagnosis， incidence， assessment tools， related factors， and intervention methods of "Hikikomori"， and puts forward the key points for future research.

Abstract:Compared with the current mainstream scale test and drug therapy， art analysis and therapy which is an effective way to deal with adolescent depression has many advantages. However， there are still many gaps and defects in its practical application and scientific research. This article introduces the application of art analysis and treatment in the diagnosis and treatment of adolescent depression at home and abroad， and discusses the shortcomings of current scientific research.

Abstract:Depression is one of the most common psychoses. Electroconvulsive therapy（ ECT） is the quickest and most efficient treatment for major depressive disorder， but its mechanism is still ambiguous. This paper summarizes the research progress of structural and functional phases of magnetic resonance imaging （MRI） in ECT for depression， and provides reference for exploring ECT-related neurophysiological changes and mechanism of action.

Abstract:Autism spectrum disorders（ ASD） and obsessive-compulsive disorder（ OCD） are highly hereditary， at the same time they have similar stereotyped and repetitive behavior on phenotype. The similarities on stereotyped and repetitive behavior and common genes of OCD and ASD are reviewed in this paper， in order to provide effective prevention and control measures for these two diseases and to lay a theoretical foundation.

Abstract: