Abstract:The role of community rehabilitation in helping schizophrenia patients returning to the normal life and society has received more and more attention. Active community intervention as a service model is widely recognized and applied internationally， and it is highly relevant to the development of community mental health services in China. This paper reviews the research on the role of active community intervention at home and abroad in the rehabilitation of schizophrenia.

Abstract:Objectives To assess the impact of childhood trauma on cognitive function in healthy young adults. Methods Three times since February 2012， the Childhood Trauma Questionnaire（ CTQ） was used to screen out healthy young people with childhood trauma and without any form of childhood trauma. These participants were then evaluated using the Wisconsin Card Sorting Test（ WCST）， the Stroop Test， Trail Making Test， Verbal Fluency Test， and the Wechs Memory Scale（ WMS）. Results The performance of young adults with childhood trauma（ n=90） was significantly different in the Verbal Fluency Test， the visual regenerative test of WMS and WCST compared with those with no childhood trauma（ n=104）. The total score of CTQ was negatively correlated with results of Visual Reproduction and Trail Making Test B， while it was positively correlated with results of WCST ervor response； the number of different types of childhood trauma was negatively correlated with the Stroop test， number of WCST correct response and partial results and partial results of WMS（ all P＜0.05）. Conclusions The cognitive function of healthy young people with childhood trauma is impaired. The more severe the trauma in childhood or the higher the number of different traumas， the worse is their cognitive function.

Abstract:Objectives To investigate the sleep quality， mood disorder and thyroid hormone level in patients with chronic subjective dizziness（ CSD）. Methods A cross-sectional self-report survey used to investigate 68 patients with CSD and 60 healthy individuals. The survey included a basic information questionnaire， Self-rating Anxiety Scale（ SAS）， Center for Epidemiologic Studies Depression Scale（ CES-D）， and the Pittsburgh Sleep Quality Index（ PSQI）. The differences in thyroid hormone levels between the two groups were compared by blood sampling assay. Results The total scores of PSQI， sleep time， sleep efficiency， sleep disorder， and sleep pill usage rate in the CSD group were significantly higher than those in the control group （P＜0.01）. The total score of SAS was（ 52.48±14.17）， and the total score of CES-D was（ 17.51±9.47）. 63.2% （43/68） of the patients have anxiety， and 66.2%（ 45/68） have depression. Comparison between the two groups' thyroid hormone levels suggested that although the mean values of the two groups were within the normal range， thyroid stimulating hormone（ TSH） levels increased in the CSD group and free triiodothyronine T3（ fT3） and free thyroxine T4（ fT4） levels decreased compared with the control group. There was a statistical difference in the proportion of patients with low fT4 between the two groups（ P＜ 0.05）. Conclusions CSD patients generally have emotional and sleep problems. Neuroendocrine factors， especially thyroid level， may be one of the influencing factors， which needs to be further studied.

Abstract:Objectives To investigate the correlation between impulsive aggression behavior and 5-hydroxytryptamine 1B receptor（ 5-HTR1B） rs6296 gene polymorphisms in both Uygur and Han patients with bipolar disorder. Methods A total of 868 patients with bipolar disorder were collected in a case-control study. There were 184 Uygur bipolar patients（ 92 males and 92 females） in the impulsive aggression group， and 326 Uygur bipolar patients（ 174 males and 152 females） in the no impulsive aggression group. There were 112 Han bipolar patients（ 50 males and 62 females） in the impulsive aggression group， and 246 Han bipolar patients （134 males and 112 females） in the no impulsive aggression group. Patients were assessed using the modified overt aggression scale（ MOAS）. The polymorphisms of rs6296 were identified by PCR direct sequencing， and the differences of 5-HTR1B rs6296 polymorphisms were analyzed. Results No significant difference in the genotype and allele frequency of rs6296 was found between the impulsive aggression group and no impulsive aggression group in Han bipolar patients（ P＞0.05）. However， significant differences in the genotype and allele frequency of rs6296 were found between the impulsive aggression group and no impulsive aggression group in Uygur bipolar patients（ P ＜0.05）. Conclusions There was no correlation between impulsive aggression behavior and 5-HTR1B rs6296 polymorphisms in Han bipolar patients. However， the impulsive aggression behavior in Uygur bipolar patients is closely related to the rs6296 genotype and allele polymorphism of 5-HTR. At the same time， allele G may increase the risk of impulsive aggression behavior in patients in Uygur bipolar group.

Abstract:Objectives To investigate the prevalence of depression and anxiety during the perinatal period and its influencing factors. Methods A total of 620 pregnancies at different stages of perinatal period were collected by convenience sampling method in Beijing from October 2017 to January 2018. All the subjects were surveyed by general information questionnaires， Patients' Health Questionnaire-9（ PHQ-9） and Generalized Anxiety Disorder-7（ GAD-7） to analyze perinatal depression， anxiety and its influencing factors. Results In this study， the detection rate of depressive symptoms in perinatal period was 11.33%（ 68/600）， anxiety symptoms 23.83%（ 143/600）， and depression with anxiety 7.83%（ 47/600）. The detection rate of depressive symptoms in early， middle and late stage of pregnancy was 15.58%（ 12/77）， 10.26%（ 8/78）， and 4.0%（ 3/75） respectively， with no statistically significant difference（ P＞ 0.05）. The detection rate of depressive symptoms was 8.75%（ 14/160） and 14.76%（ 31/210） within 6 months and 6 months after delivery， with no statistically significant difference（ P＞0.05）. The detection rate of prenatal anxiety was 28.57%（ 22/77）， 23.08%（ 18/78） and 9.33%（ 7/75） respectively， and the difference was statistically significant（ P＜ 0.05）. Postpartum was 25.63% （41/160）， 26.19%（ 55/210）， and the difference was not statistically significant（ P＞ 0.05）. Logistic regression analysis found that the risk factors for depressive symptoms in perinatal period were not full-time（ OR：2.27， 95%CI：1.33-3.86，P＜ 0.01）. The risk factors of perinatal anxiety symptoms were monthly income lower than 5 000 yuan（ OR：1.60， 95%CI： 1.02-2.50，P＜0.05）， and non-full-time（ OR：1.85， 95%CI：1.15-2.97，P＜0.05）. Conclusions PHQ-9 and GAD-7 can effectively detect depression and anxiety symptoms in perinatal period. There is a certain proportion of depression and anxiety in pregnancy and postpartum. A common risk factor for perinatal depression and anxiety symptoms is job insecurity.

Abstract:Objectives To explore the effect and safety of aripiprazole for risperidone-induced increased prolactin level in male schizophrenia patients. Methods After using risperidone for 4 weeks， a total of 60 patients were randomized to study group（ risperidone combined with aripiprazole，n=30） and control group（ risperidone，n=30）， and then receive treatment until the end of the 8th week. Serum prolactin levels were measured at baseline， the end of the 4th week and the 8thweek. Positive and Negative Syndrome Scale （PANSS） and Udvalg for Kliniske Undersogelser（ UKU） side effect rating scale were assessed at baseline， the end of the 4th week and the 8th week. Results After 4 weeks' risperidone treatment， the PRL level of both groups increased significantly（ P＜0.01）. At the end of the 8th week， PRL level of study group was significantly reduced than it at the 4th week（ P＜0.01）， and the difference from control group was statistically significant（ P＜ 0.01）. The PANSS score of both groups decreased significantly（ P＜ 0.01）， however there was no statistically significance between two groups. The most common adverse reactions in the two groups were breast development in male， fatigue， sleepiness， sedentary dysfunction， dystonia and tremor， but there was no significant difference in the incidence of these adverse reactions between the two groups（ P＞0.05）. Conclusions Risperidone can lead to increasing PRL level of male schizophrenia patients and aripiprazole combined treatment is effective and safe for risperidone-induced hyperprolactinemia， without increase of the incidence of side effects.

Abstract:Objectives To investigate the differences and correlations between the neurological soft signs（ NSS） and cognitive functions for first-episode schizophrenia patients. Methods From October 2015 to April 2016， 36 patients with first-episode schizophrenia and 37 healthy controls were selected. Subjects' cognitive functions were assessed using the Rapid Visual Information Processing（ RVP） and Stockings of Cambridge（ SOC） in the Cambridge Neuropsychological Test Automated Battery（ CANTAB）. Cognitive function assessment was performed to analyze differences in attention， memory， and executive function between the two groups. The Cambridge Neurological Inventory's（ CNI） soft sign subscale was used to detect differences in neurological soft signs between the two groups and to understand the association between NSS and clinical symptoms and cognitive function. Results Compared with the healthy control group， the schizophrenia group's average number of moves in the SOC test（ 4 moves） was not statistically significantly different（ P＞0.05）， while all the other RVP and SOC indicators were statistically significantly different（ P＜0.05）. The total score of CNI soft signs， the original reflex score and the exercise coordination score in the schizophrenia group were 9.50 （7.00， 13.75）， 2.00（ 2.00， 2.00）， and 8.00（ 5.00， 11.75）， respectively， which were all significantly higher than those of the healthy control group［ 4.00（ 3.00， 5.00）， 2.00（ 2.00， 2.00）， 2.00（ 0， 3.00）， P＜0.05］. The total score of the CNI soft sign subscale was moderately positively correlated with age（ r=0.553， P＜0.001）， and had no correlation with gender and years of education（ P＞0.05）. Controlling for age， the primary reflex score of the CNI soft sign subscale was moderately positively correlated with the negative symptom score in the Positive and Negative Syndrome Scale（ PANSS， r=0.412， P=0.024）. The motor coordination score was correlated with RVP （P ＜ 0.05）， and was moderately negative related to the number of tasks completed with the minimum number of SOC moves（ r=-0.419， P=0.001）. The total score of the CNI soft sign subscale was correlated with all RVP indicators （ P＜ 0.05） and was slightly negatively related to the number of tasks completed with the minimum number of SOC moves（ r=-0.395， P=0.002）. Conclusions NSS and cognitive function both have different degrees of damages in patients with first-episode schizophrenia. And there is a certain correlation between the two.

Abstract:Objectives This study focused on the effect of histone lysine methyltransferase（ EZH） 1 on schizophrenia and its associated behavioral disorders. Methods Seventy C57BL/6 mice were choosen to the following four experiments.（ 1）Expressions of EZH1 and EZH2 in brain regions and organs of mice were regions and organs except the cerebellum.（ 2）After acute injection of quinpirole， the expression of EZH1 in PFC significantly increased（ P＜ 0.05）， while the expressions of EZH2， KDM6A， KDM6B and UTY did not significantly change（ P＞ 0.05）.（ 3）Compared with mice injected with saline， the expression of EZH1 in PFC of mice injected with clozapine and haloperidol significantly decreased（ P ＜ 0.05）， while the expression of EZH2 did not significantly changed（ P ＞ 0.05）.（ 4）In the social ability test， EZH1 knockdown increased the time for mice to spend in new cages and to sniff strange mice（ P＜0.05）. In the forced swimming test， EZH1 knockdown reduced the immobility time of the mice and increased the swimming time in mice（ P ＜ 0.05）. Conclusions EZH1 is highly expressed in various brain regions of mice， especially in PFC of quinpiroleinduced schizophrenia mice. EZH1 is extremely sensitive to antipsychotic drugs， and its knockdown increases the social ability and reduces behavioral despair of mice. detected by real-time quantitative polymerase chain reaction（ PCR） and Western Blot.（ 2）Mice were given an intraperitoneal injection with 3 mg/kg quinpirole hydrochloride to establish an animal model of schizophrenia， and the control group was given an equal volume of physiological saline. The expressions of histone modificationrelated proteins in the prefrontal cortex（ PFC） of mice were measured at 10 min after administration（. 3）Mice were given intraperitoneal injection with 5 mg/kg of clozapine or 0.5 mg/kg of haloperidol， and the control group was injected with an equal volume of physiological saline. The expressions of EZH1 and EZH2 in PFC was measured at 21 days after injection.（ 4）AAV-m-EZH1-shRNA was injected into the medial PFC of the mice to knock down EZH1， and the control group was injected with interfering shRNA. The behaviors of the mice were measured at 2 weeks after injection. Results （1）EZH1 is highly expressed in the brain regions including the prefrontal cortex， hippocampus， cerebral cortex， subcortical， cerebellum and brainstem， but is low expressed organs including the heart， kidney， liver， lung， stomach and intestines. EZH2 was low expressed in various brain

Abstract:Objectives To investigate the clinical effects of experiential musical therapy in the rehabilitation of patients with chronic schizophrenia. Methods A total of 60 inpatients with chronic convalescent schizophrenia were divided into experimental group and control group. The patients in experimental group were treated with experiential musical therapy for 12 weeks. The Positive and Negative Symptom Scale （PANSS） and Global Assessment Scale（ GAS） were used to evaluate the changes of mental symptoms in the two groups before and after the study. The Chinese version of the Interpersonal Reactivity Index-C scale（ IRI-C） and Texas Social Behavior Inventory（ TSBI） were used to assess the social function of the two groups before and after the study. Results After treatment， there were significant differences between the two groups in the PANSS score（ t=2.77，P=0.01）， the GAS score（ t=3.16，P＜0.05）， and the TSBI score（ t=3.07，P＜0.01）， but there was no significant difference in the IRI-C score（ t=0.47，P=0.64）. Conclusions It is found that experiential musical therapy can improve the mental symptoms， self-efficacy and social function rehabilitation of patients with chronic schizophrenia.

Abstract:Objectives To investigate the differences of serum interleukin-6（ IL-6） level in schizophrenic patients with different illness duration， and the correlation between serum IL-6 level and cognitive impairment. Methods The cross-sectional study was conducted. A total of 65 schizophrenic patients treated with olanzapine monotherapy were enrolled in the study. All the patients were grouped into two groups： the medium course group（ 1-10 years， n=33） and the long course group（ ＞10 years，n=32）. The basic information of patients was collected. Positive and Negative Symptoms Scale（ PANSS） was applied to evaluate the psychiatric symptoms. Cognitive tests were carried out using Trail Making Test（ TMT）， Brief Assessment of Cognition in Schizophrenia（ BACS）， Hopkins Verbal Learning Test-revised（ HVLT-R）， Brief Visuospatial Memory Testrevised（ BVMT-R） and Continuous Performance Test-identical pair test（ CPT-IP）. The serum IL-6 level of all patients were measured. Results （1） The level of IL-6 in the medium course group and the long course group was 3.05（ 1.67， 4.26） pg/ml and 1.62（ 1.52， 3.43） pg/ml respectively， and the difference was statistically significant（ Z=-3.09， P＜ 0.05）.（ 2） There was a negative correlation between IL-6 and the TMT score in the long course group（ r=-0.39，P＜ 0.05）. Conclusions There are significant differences in IL-6 levels among patients with different course of disease. IL-6 levels may be negatively correlated with executive function in patients with course of disease more than 10 years.

Abstract:People with schizophrenia in mental disorders have high risk of dangerous behaviors， and their dangerous behaviors often threaten the safety of society， families， health care workers and their own personal and property， affect social harmony， security and stability， and have become an urgent social problem to be solved. This paper reviews the research progress of factors affecting the risk behaviors of schizophrenia patients from the perspectives of biology， psychology and sociology.

Abstract:Objectives To evaluate the psychometric property of the Insomnia Severity Index（ Chinese version） in students of a commercial school. Methods A total of 3 969 students of a commercial school were selected. Their sleep quality， insomnia， anxiety， daytime sleepiness， and depression were evaluated by the Pittsburgh sleep quality index（ PSQI）， the Insomnia Severity Index（ ISI）， Self-Rating Anxiety Scale（ SAS）， Epworth Sleepiness Scale（ ESS）， Beck Depression Inventory（ BDI）， respectively. Their general information was also gathered. After 9 months， 73% of the students（ n=2 915） were re-evaluated by the ISI. Results The score of ISI in the first test were 5.8±4.6（ 0-28）， in a skewed normal distribution. It had a single factor structure （interval variance value was 52%）； the item loading ranged from 0.62 to 0.80； KMO=0.87； Bartlett spherical test result was P ＜ 0.001； the correlation coefficient between the item and the total score was 0.63-0.79； Spearman-Brown semi-reliability and Cronbach alpha coefficients were 0.75 and 0.84（ P＜ 0.001）. There was a significant correlation between the first test ISI score and the ESS score， BDI score and SAS score， while the ISI score was not statistically related to the PSQI score. The effect size（ Cohen's d） of the total score and each item of ISI between the first test and the second test was less than 0.1， except for item 5（ Cohen's d=0.361）. Conclusions The ISI（ Chinese version） has good psychometric property， so it is suitable for evaluating insomnia among adolescents. Moreover， attention should be paid to the prevalence of insomnia in these young adults（ 30.2%）

Abstract:Objectives To examine the reliability and validity of the Binge Eating Scale（ BES） in a sample of Chinese adolescents. Methods A survey was conducted among 1 266 adolescents aged from 12 to 18 with BES， Dutch Eating Behavior Questionnaire（ DEBQ）， and Self-Control Scale（ SCS） from September 2017 to December 2017. Results （1） Exploratory Factor Analysis（ EFA） revealed that factor model fit well.（ 2） The validity test showed that the correlation between BES and other calibrations was significant（ r=0.168-0.500， P ＜ 0.01）.（ 3） Reliability analysis showed that the Cronbach's α coefficient of the scale was 0.805， and the retest reliability was 0.768. Conclusions BES presents good reliability and validity in Chinese adolescents.

Abstract:Objectives To explore the residual symptoms and its influencing factors after the treatment of bipolar disorder in the acute phase of depression. Methods This is a single center， cross-sectional study. Clinical data from the medical records of 130 outpatient or hospitalized patients with bipolar disorder（ BD） whose last episode was depression and were treated in Beijing Anding Hospital between February and December 2016 was collected. A total of 121 cases were included in this study. Patients' demographic and clinical data were collected using a mix of standardized scales and interviews. Results A total of 121 patients were interviewed in this study. The proportion of patients with residual depressive symptoms was 23.1%（ 28/121）. Gender（ χ2 =17.90， P ＜ 0.01）， acute phase with sleep disorders（ χ2 =7.37，P=0.01）， episode times in the past two years （Z=-2.46，P=0.01） were significantly different between clinical remission group and residual symptom group. Multiple logistic regression analysis demonstrated that male， acute phase with sleep disorders， more episode times in the past two years were independently associated with residual depressive symptoms. Patients with residual depressive symptoms were more depressive and significantly more impaired than the remission group. Conclusions Residual depressive symptoms may occur in some patients after the acute phase of bipolar depression. Being male， more episode times in the past two years were significantly associated with residual depressive symptoms. Residual depressive symptoms have negatively impact on patients so we should strive to enhance treatment plans to improve the prognosis.

Abstract:Objective To investigate the relationship between bone morphogenetic protein-7（ BMP- 7） level and the severity and prognosis of patients with acute cerebral infarction（ ACI）. Methods A total of 105 patients with ACI（ ACI group） and 105 healthy people（ control group） were recruited from September 2017 to March 2018. The serum BMP-7 level was measured and the clinical data of all patients were recorded. The patients in ACI group were followed up for 3 months and their Modified Rankin Scores（ mRS） were recorded. The difference of BMP-7 level in ACI group and healthy control group， and the relationship between BMP- 7 level and severity and prognosis in ACI group were observed. Results The level of BMP-7 in ACI group was lower than that in the control group. The result of Logistic regression showed that smoking， hypertension， diabetes， coronary heart disease， cystatin C， glycosylated hemoglobin， and BMP-7 levels are closely related to the incidence of ACI（ P ＜ 0.05）. The level of BMP-7 in less severe ACI group was 61.54（58.46，66.32）， which was higher than that in severe group 54.69（51.18，58.27）. The level of BMP-7 was negatively correlated with the score of the National Institutes of Health Stroke Scale（ NIHSS）（ r=-0.702，P ＜ 0.05）. The level of BMP-7 in patients with poor prognosis was lower than that in patients with good prognosis（ P ＜ 0.05）. There was a negative correlation between the level of BMP-7 and mRS score of ACI patients（ r=-0.493，P＜ 0.05）. Conclusions BMP-7 is an influential factor in the pathogenesis of ACI， and the level of BMP-7 can be used to evaluate the severity of ACI and predict the prognosis of patients with ACI.

Abstract:Objectives To observe the therapeutic effect of Jujube seeds extract on the sensitisation of rat nicotine behaviour， and to explore its neurochemical mechanism. Methods Thirty-six adult Sprague- Dawley（ SD） rats were divided into normal saline group（ group A）， single nicotine group（ group B）， nicotine behavioural sensitisation model group（ group C）， and jujube seed low-dose treatment group（ group D）， high dose treatment group（ group E） and high dose of jujube group（ group F）. Groups C， D and E were injected subcutaneously with nicotine［ 0.4 mg（/ kg·d）］ for 7 days. Groups A， B and F were injected with the same volume of normal saline for 7 days， and then discontinued for 3 days. During the withdrawal period， the D， E and F groups were administered with the jujube extract once a day respectively（ low dose group： 60 mg/kg， high dose group： 180 mg/kg）， and groups A， B and C were administered with equal volume of drinking water. On the third day， 1 hour after gastrointestinal administration， except for the A and F groups， the other groups of rats were given an activated dose of nicotine（ 0.4 mg/kg）. Immediately after using the rat spontaneous activity detection system to detect the spontaneous activity of rats within 60 min， then the ultra-high performance liquid chromatography（ HPLC） was used to detect the dopamine content in rat striatum. Results Compared with group A and group B， the spontaneous activity of rats in group C increased significantly， while the sensitisation of

Abstract:Objectives To evaluate the screening effect of Ipad-based cognitive assessment and training software（ with screening and training functions） for elderly patients with mild cognitive impairment. Methods In this study， we selected the elderly individuals who underwent physical examination in Xiaotangshan Hospital of Beijing as the research subjects， and used Ipad cognitive assessment and training software and Beijing version of Montreal Cognitive Assessment（ MoCA） to conduct screening and evaluation. Results The detection rate of cognitive impairment in the elderly was 23.53% using MoCA based on the different educational years and different thresholds of MOCA score in the Beijing version. The detection rate of mild cognitive impairment in the elderly was 24.85% using Ipad cognitive assessment and training software. There was no statistical difference between the two methods（ P ＞ 0.05）. The results of the two methods were consistent（ Kappa=0.755，P ＜ 0.001）. Conclusions Ipad cognitive assessment and training software can be used for the preliminary screening of cognitive impairment in the elderly population.

Abstract:Objectives To explore the correlation between plasma amyloid β protein 40， 42（ Aβ40， Aβ42） levels and their ratios in depressed patients without cognitive impairment. Methods A total of 70 depressed patients without cognitive impairment who had not gone through systemic treatment were selected as the experimental group. During the same period， a total of 70 healthy cases were selected as the control group. The plasma levels of Aβ40 and Aβ42 in each group were measured. The Hamilton Depression Scale 24（ HAMD-24） was used to assess the severity of depression. Results There was no significant difference in plasma Aβ40 level between patients and controls（ P=0.39）. The level of plasma Aβ42 in the patient group was significantly lower than that in the control group（ P=0.02）， and the level of Aβ40/Aβ42 was significantly higher than that in the control group（ P=0.01）. The results were not affected by age and the differences were statistically significant. Aβ42 level was negatively correlated with HAMD24 total score（ r=-0.401， P=0.015）， while Aβ40/Aβ42 was positively correlated with HAMD-24 total score（ r=0.461， P=0.005）. Conclusions Depressed patients without cognitive impairment have decreased serum Aβ42 levels and increased Aβ40/Aβ42 levels. The changes of Aβ42 and Aβ40/Aβ42 levels may be associated with the onset of depression.

Abstract:In order to strengthen the training of psychiatrists， improve the mental health service at the primary level and establish a sound mental health system， it is essential to carry out the training of psychiatrists. Through the training program for psychiatrists， students will study theories， clinical practice， community practice. At the same time， efforts should be made to optimize the teaching methods including teacher ability and teaching concept and form， to utilize mixed teaching methods with intensive training to enhance learning outcomes and to conduct a rigorous comprehensive assessment to evaluate training outcomes. Through the systematic training of the psychiatric transfer student， the psychiatric transfer students should master the basic theoretical knowledge and basic clinical skills， and they should be familiar with the mental health service model， and meet the basic requirements of qualified psychiatrists， thus further improving the medical institutions at all levels， especially county-level medical institutions， and increasing the accessibility of mental health services and alleviating the shortage of mental health human resources.

Abstract:The tachykinin/ tachykinin receptors are widely distributed in the central nervous system of the brain， especially in the limbic system associated with emotion. Accumulating evidence has indicated that the tachykinin/ tachykinin receptors may contribute to the pathophysiology of depression. This article reviews the research on the relationship between tachykinin/ tachykinin receptors and depression， and it may enrich the understanding of the pathological processes of depression and provide insights into therapeutic approaches for its treatment.

Abstract:The myelin sheath is a layer of myelin membrane that is wrapped around the axons. It plays an important role in the rapid conduction of nerve electrical signals. The production of myelin is a complex dynamic process in which signals from axons and extracellular matrices participate and play a key role. Neuregulin 1（ NRG1） is a group of trophic factors. Studies have shown that axons and Schwann cells can secrete NRG1， and NRG1 plays an important role in the differentiation， proliferation， migration and myelination and repair of Schwann cells. However， the regulation of NRG1 with other signaling proteins involved in myelination （laminin-211， Maf， Gab1， E-cadherin） is not fully understood. This article is mainly to review this to further explain the molecular mechanism of myelination.

Abstract:Uric acid（ UA） is produced by human exogenous intake and purine compounds in liver metabolism， which is known to have an impact on hypertension， diabetes， chronic kidney disease and gout. Studies have shown that it is a risk factor for cardiovascular disease. However， its impact on cognitive function is still controversial. With the aging of the social population， the number of people with cognitive dysfunction increases， which is a great burden for society and the family. At present， there is no good treatment for cognitive dysfunction， and it is extremely important to actively control risk factors and prevent the occurrence of cognitive dysfunction.

Abstract:With the development of society， the number of people suffering from psychological disorders is increasing. Due to the lack of knowledge in psychiatry， most of the patients turn to the general hospitals. There may be a considerable number of missed diagnosis. Consultation-liaison psychiatry has developed and improved gradually， and it is of great clinical significance to explore a consultation model suitable for China's specific situations. As the consultation-liaison psychiatry service is for patients with psychological problems in the general hospitals， the level of required professional skills is higher. The service mode of consultation-liaison psychiatry， the development of the consultants， and the effectiveness of consultation-liaison psychiatry are worthy of further discussion by clinicians.

Abstract:Compassion-focused therapy（ CFT） is an increasingly popular psychotherapy that is considered to be the third wave of psychotherapy and has received widespread attention in recent years. A growing body of clinical practice evidence suggests that CFT has a proven effect in relieving symptoms such as depression， anxiety， shame， and self-criticism etc. This article reviews the origin， theoretical basis， therapeutic effectiveness， intervention methods of CFT， and it looks forward to future research. It also hopes to provide a basis for future researchers to promote mental health intervention.