Abstract:Severe mental disorders are getting more and more attention from all sectors of society. The community case management of mental illness in China started later than in western countries. There is no unified case management model. This paper reviews the research on the effect of community case management on patients with severe mental disorders.

Abstract:Objectives To investigate the effect of quetiapine on the expression of PDLIM5 mRNA in peripheral blood of patients with bipolar depression. Methods Totals of 21 bipolar depression patients（ patient group） and 23 one-level relatives without mental health were recruted. Patients were treated with quetiapine for 8 weeks. Montgomery and Asperger Depression Rating Scale（ MADRS） was evaluated and PDLIM5 mRNA expression level in peripheral blood was also tested before treatment and 2 weeks，4 weeks， 8 weeks after treatment respectively. Results After 2 and 4 weeks of quetiapine treatment， there was no significant difference in MADRS score in patient group before and after treatment（ P ＞ 0.05）. After 8 weeks treatment， MADRS scores in patient group were significantly decreased， and the difference was statistically significant （P ＜ 0.01）. Before treatment， PDLIM5 mRNA levels in peripheral blood of patient group were significantly lower than those in control group（ P＜0.01）. After 2 and 4 weeks treatment， the expression of PDLIM5 mRNA in peripheral blood of patient group showed no significant change compared with that before treatment. The expression of PDLIM5 mRNA in peripheral blood of patient group increased after 8 weeks treatment， and the difference was statistically significant（ P＜0.05）. There was no significant correlation between the total score of MADRS and the expression of PDLIM5 mRNA in peripheral blood of patients with bipolar depression before and after treatment， and the difference was not statistically significant（ P ＞ 0.05）. Conclusions Quetiapine can effectively improve the depressive symptoms of patients with bipolar depression but does not affect the expression of PDLIM5 in peripheral blood.

Abstract:Objectives To explore the relationship between neuroticism， depression and cognitive function in patients with first-episode depression. Methods The 17-item Hamilton Depression Scale（ HAMD-17）， Eysenck Personality Questionnaire（ EPQ）， Wechsler Adult Intelligence Test（ WAIS-RC） were used to evaluate and study 156 cases of patients with first-episode depression. Results （1） In depressive patients， the neurotic personality was positively correlated with the total score of HAMD-17（ r=0.301，P＜ 0.01） but was negatively correlated with Verbal IQ（ VIQ）（ r=-0.276， P＜ 0.01）， Performance IQ（ PIQ）（ r=-0.330，P＜ 0.01） and Full IQ（ FIQ）（ r=-0.376，P ＜ 0.01）.（ 2） Depressive symptoms played a partial mediating role between neurotic personality and WAIS-IQ， the mediator effect was 38.7%. Conclusions Neurotic personality of first-episode depression patients affected cognitive function through depressive symptoms.

Abstract:Objectives To evaluate the efficacy of Danggui-Chengqi Decoction combined with lithium carbonate in the treatment of cognitive dysfunction in patients with manic episodes. Methods A total of 123 patients were randomly divided into 41 cases of Danggui-Chengqi Decoction group， 42 cases of -4.009，P=0.028）； the delayed recall score was higher in the combined group than that in the Danggui-Chengqi Decoction group（ t=-9.130，P=0.001） and the lithium carbonate group（ t=-6.447，P=0.015）.（ 3） The visualspatial difference and the difference in YMRS score were slightly positively correlated in the combined group （r=0.326，P=0.046）. In the Danggui-Chengqi Decoction group， there was a slight positive correlation between the visual-spatial difference and the difference in the YMRS score（ r=0.310，P=0.045）， and between the delayed recall difference and the difference in the YMRS score（ r=0.370，P=0.017）. Conclusions Danggui-Chengqi Decoction combined with lithium carbonate treatment can improve the cognitive function of patients with manic episodes， and the correlation with the improvement of mental symptoms is not strong. lithium carbonate group and 40 cases of Danggui-Chengqi Decoction combined with lithium carbonate group （combined group）. All patients were followed up for 8 weeks. Psychiatric symptoms and cognitive function were assessed before and after treatment using the Young Mania Rating Scale（ YMRS） and Repeatable Battery for the Assessment of Neuropsychological Status（ RBANS）. Results （1） The difference of YMRS between the three groups was statistically significant（ F=8.683，P＜0.001）. The difference of YMRS between the Danggui- Chengqi Decoction group and the lithium carbonate group was lower than that of the combined group（ t=-4.577， P＜0.001；t=-3.309，P=0.004）.（ 2） After treatment， the total scores of RBANS and its factor scores increased in all three groups（ P＜0.01）. In pairwise comparison， the total scores of RBANS and visual-spatial were lower in Dangui-Chengqi Decoction group than those in the combined group（ t=-24.500，P ＜ 0.001；t=-5.644， P=0.016）； the verbal ability score in the lithium carbonate group was lower than that in the combined group（ t=

Abstract:Objectives To systematically evaluate the efficacy of Naikan cognitive therapy in PANSS patients with schizophrenia in China. Methods Databases including PubMed、Embase、Cochrane、Medline、 Web of science、 CBM、CNKI、VIP、WanFang Data、TWS. We searched databases to collect PANSS related randomized controlled trials of patients with schizophrenia treated used Naikan cognitive therapy. RevMan 5.3 software was used for meta-analysis. Results A total of 9 randomized controlled trials were included， 389 cases of experimental group and 393 cases of control group.The results showed that the total PANSS score，positive symptoms score，negative symptoms score and general psychopathological symptoms score of schizophrenia patients could be reduced by Naikan cognitive therapy（ P＜0.05）. Conclusions To some extent， Naikan cognitive therapy is helpful to improve the clinical symptoms of schizophrenia， especially general psychopathological symptoms and negative symptoms.

Abstract:Objectives To explore the impact of case management on the cognitive function of patients with severe mental disorders. Methods A total of 240 patients were recruited from Chongqing from November 2017 to January 2018. Patients were divided into a routine follow-up control group（ n=115） and a case management group（ n=125） using a single-group consent to Zelen's randomized controlled trial. The control group was followed up according to the requirements of the management criteria for severe mental disorders. The case management group went through a variety of cognitive rehabilitation activities. The revised Wechsler Adult Intelligence Scale subscales-Digital Width and Symbol Subscale， Language Fluency Test， Connection Test- Awere used to evaluate all the patients at the pre-intervention and 3 months， 6 months， and 12 months after the intervention time marks. Results The results of repeated measurement variance analysis showed that there were significant differences between the two groups in the scores of Digital Width and Symbol Subscale， Language Fluency Test， Completion Time and Error Number of Connection Test A（ F=11.115，6.918，6.128，21.523，4.457， 5.693，P＜0.01）. The time main effect（ F=141.064，158.939，468.552，419.484，70.981，104.701， P＜0.01）， and interaction（ F=167.652，168.388，384.422，235.782，53.549，19.324， P ＜ 0.01） were both statistically significant. Conclusions Case management can improve the cognitive function of patients with severe mental disorders.

Abstract:Objectives To explore the effects of assertive community treatment on the quality of life in schizophrenia patients and its influencing factors. Methods A total of 215 registered stable schizophrenia patients in community were recruited and divided into intervention group and control group by random number table. The intervention group received assertive community treatment， while the control group received routine community mental health services. After 12 months of intervention， the patients were followed up for 12 months. The intervention group and the control group were assessed with the Schizophrenia Quality of Life Scale（ SQLS） at the time of admission， 6 months， 12 months and 24 months after admission， respectively. Results There was significant group main effect in psychosocial subscale（ F=7.687，P＜0.01）， and it was lower in the intervention group than in the control group（ P＜0.05）. With the increase of time， the scores of subscales showed a downward trend（ P ＜ 0.05）. There was interaction between groups and intervention time in psychosocial and motivation/ energy subscales（ F=3.049，16.257；P＜0.05）. Generalized estimation equation analysis of total quality of life score change showed that active community intervention and its time effect， number of hospitalizations and number of risky behaviors were the influencing factors. The total quality of life score of intervention group was 7.509， lower than that of control group， and the difference was statistically significant（ χ2=14.533，P＜ 0.01）. The intervention group had time effect， and the SQLS score changed with time， while the control group had no time effect. Every time the number of hospitalizations increased， the average score of SQLS increased by 1.930 points（ χ2=13.003， P＜ 0.01）. The average score of SQLS increased by 4.448 points for every increase in the number of dangerous behaviors（ χ2=12.386，P ＜ 0.01）. Conclusions Assertive Community Treatment can improve the quality of life of schizophrenia

Abstract:Objectives To investigate the sex differences in neurocognitive function in patients with first-episode schizophrenia（ FES） and chronic schizophrenia（ CSz）. Methods A total of 53 patients with FES and 104 patients with CSz were enrolled， and 52 healthy controls（ HC） were recruited at the same time. The three groups were evaluated for neurocognitive function using the Chinese version of the MATRICS Consensus Cognitive Battery（ MCCB）. Results （1） The comparison of sex differences in MCCB test scores showed that the interaction between groups and sexes was not statistically significant（ F=0.80， P=0.67）； the main effects of the group were significant， and the scores of 6 MCCB subtests and the total neurocognitive scores were all significantly different； the main effect of gender was statistically significant in the visual learning memory test （F=5.12， P=0.03）. The females in the CSz group were better than the males in visual learning memory（ t=2.44， P=0.02）； There was no significant difference between sexes in the FES and the HC group（. 2） Compared with the HC group， the scores of the MCCB total scores and the scores of the subtests in the FES and CSz groups were all statistically different， except for vocabulary learning and memory. Compared with the CSz group， the total score of the neurocognitive dimension in the FES group was better（ t=2.36， P=0.05）. Conclusions The cognitive function of both the first-episode and chronic schizophrenia patients is impaired and the visual learning and memory impairment in male chronic patients are more serious than in female patients.

Abstract:Objectives To initially investigate the influencing factors of aggression in home-based patients with schizophrenia. Methods From July 2017 to November 2018， a total of 253 patients with schizophrenia who had aggressive behavior in the Nan'an District of Chongqing were included in the study， and 2 424 patients with stable schizophrenia without aggressive behavior were selected as the control group. The survey was conducted using the Insight and Treatment Attitude Questionnaire（ ITAQ） and the Modified Overt Aggression Scale（ MOAS）. Results （1） There were significant differences in age， education level， onset age， the prolonged period of treatment， number of hospitalizations， self-knowledge， and medication status between the two groups.（ 2） Multiple linear regression showed that young patients， early onset， and low level of education were the influencing factors of aggressive behavior. Conclusions The occurrence of aggression in patients with schizophrenia is related to a variety of factors. It is necessary to strengthen the monitoring of young， early onset and low-education schizophrenia patients.

Abstract:Objectives To study the effect of community mental rehabilitation club model on cognitive function and quality of life of first-episode schizophrenia patients. Methods By convenience sampling method， 160 patients with first-episode schizophrenia in the convalescent stage discharged from Chongqing Mental Health Center from February 2017 to December 2017 were selected as the study subjects. According to the random alphabetical method， they were divided into the study group and the control group， with 80 patients in each group. The patients in the control group received the routine nursing intervention， while the patients in the study group received club-mode rehabilitation training in addition to what the control group received. The severity of illness， cognitive function， and quality of life of schizophrenic patients were assessed with the Positive And Negative Symptoms Scale（ PANSS）， the Chinese version of the MATRICS Consensus Cognitive Test（ MCCB） and the Schizophrenia Quality of Life Scale（ SQLS）. Results There was no significant difference in PANSS total score， positive factor score， negative factor score， and general psychopathological symptom score between the two groups before treatment（ P＞0.05）. After one year of treatment， these scores significantly decreased for both groups（ P＜0.05）， and the scores of the study group were significantly lower than those of the control group （P＜0.05）. There was no significant difference in MCCB scores between the two groups before treatment（ P＞ 0.05）. After one year of treatment， the patients' processing speed， attention alertness， working memory， speech learning and memory， visual learning and memory， reasoning and problem-solving ability and social cognitive score significantly improved（ P＜0.05）， and the scores of the study group were significantly higher than those of the control group（ P＜0.05）. There was no significant difference in the scores of psychosocial， motivational energy， and symptoms and side effects between the two groups before treatment（ P＞ 0.05）. After one year of treatment， these scores significantly decreased（ P＜0.05）， and the scores of the study group were significantly lower than those of the control group（ P＜ 0.05）. Conclusions Community mental rehabilitation club model has good rehabilitation effect for first-episode schizophrenia patients， can significantly improve the symptoms of cognitive impairment and improve the quality of life of patients.

Abstract:Objectives To investigate the relationship between social support and serum neurological function level， negative symptoms and depressive symptoms in patients with schizophrenia. Methods From September 2014 to June 2018， a total of 92 patients with first-episode schizophrenia admitted to Panzhihua Third People's Hospital were divided into the control group and the study group with 46 patients in each group according to the random number table method. Patients in the control group were routinely taking antipsychotic drugs， and patients in the study group received social support intervention and antipsychotic medication， and the effect was evaluated after one month. The Social Support Rating Scale（ SSRS） scores before and after intervention were compared between the two groups. The study group was further divided into high SSRS score group and low SSRS score group with 23 cases in each group， according to the median SSRS score after the intervention. The differences in serum neurotransmitters［ dopamine（ DA）， γ-aminobutyric acid（ GABA）， acetylcholine （Ach）］， neurotrophic factor［ brain-derived neurotrophic factor（ BDNF）， nerve growth factor（ NGF）］， Scale for the Assessment of Negative symptoms（ SANS） scores， and the Calgary Depression Scale for Schizophrenia （CDSS） scores were compared across the control group， the study group and high and low SSRS score groups. Results The SSRS scores of the study group were higher than those of the control group. The level of DA and GABA was higher than that of the control group. The level of Ach was lower than that of the control group. The level of BDNF and NGF was higher than that of the control group. The scores of SANS and CDSS were lower than those of the control group（ P＜0.05）. The change of the above indicators before and after the intervention of the high SSRS score group was larger than the low SSRS score group（ P＜0.05）. Conclusions Social support intervention can effectively optimize the condition of patients with schizophrenia. The degree of social support may be one of the important factors affecting the patient's condition.

Abstract:Objectives To explore the characteristics of intertemporal choice in patients with generalized anxiety disorder（ GAD）. Methods A total of 49 patients with GAD， 67 patients with depressive disorder（ D） and 71 healthy controls（ HC） were selected. Using the intertemporal choice paradigm， the discount rate K and the area under the curve（ AUC） were used to represent the decision-making tendency of individual intertemporal choice. A mixed experiment design using Group × Amount Size × Delay Time. Results （1） There was no significant difference in the AUC values across the three groups in the intertemporal choice.（ 2） The analysis of AUC values of different amount sizes showed that there was no statistically significant difference in the amount size in the GAD group and the D group. As opposed to the Absolute Quantity Principle， the difference of the amount size in the HC group was statistically significant.（ 3） The analysis of different delay time points showed that the difference of AUC value in some short time points in the GAD group was statistically significant in the ￥50 task. The discounting trend of the D group HC group were different from that of the GAD group. In the ￥500 task， the difference of AUC value was statistically significant at different time points in the GAD group. The difference of AUC value was statistically significant at some time points in the HC group. The difference was not statistically significant in the D group. Conclusions Patients with GAD have different discounting trends than those with depression and healthy controls and have more sensitive time perception.

Abstract:Objectives To study the association between neurobiochemical markers and cognitive dysfunction in patients with depression. Methods Patients with depression were divided into cognitive dysfunction group and normal cognitive function group according to the Chinese version of Montreal Cognitive Assessment（ MoCA）. Multivariate analysis was performed with binary logistic regression model to identify the association between serum homocysteine（ Hcy）， corticoid（ COR）， dehydroepiandrosterone（ DHEA）， interleukin-18（ IL-18）， brain-derived neurotrophic factor（ BDNF） and cognitive dysfunction in patients with depression. Results After adjusting for gender， age， educational years and the 24-item Hamilton Depression Scale（ HAMD-24） scores， serum Hcy， COR， DHEA and IL-18 were associated with cognitive dysfunction in patients with depression， and their odds ratio（ OR） were 2.458（ 95%CI： 1.343-4.918）， 2.034（ 95%CI： 1.217- 4.837）， 1.954（ 95%CI： 1.122-4.129） and 2.173（ 95%CI： 1.226-4.909）， respectively. Conclusions Serum Hcy， COR， DHEA， and IL-18 were associated with cognitive dysfunction in patients with depression， which might be used in the prediction of cognitive dysfunction in patients with depression.

Abstract:Objectives To explore the life satisfaction status and influencing factors in primary level mental health workers. Methods A total of 478 primary level mental health workers were randomly selected from Chongqing primary health care institutions from November 2015 to July 2016. The general social demographic scale and the Satisfaction with Life Scale（ SWLS） were used to evaluate primary level mental health workers. Results （1） There was a positive correlation between life satisfaction and years of mental health work （r=0.183）， educational level（ r=0.445） and professional title（ r=0.113）.（ 2） There were significant differences in life satisfaction among primary mental health workers across different marital status（ F=15.245） and location of residence（ F=52.198）（. 3） Multivariate linear regression analysis showed that marriage， residence， culture， total working years， years of mental health work were the influencing factors of life satisfaction. Conclusions There are regional differences in life satisfaction among the primary mental health workers in Chongqing， and life satisfaction is affected by many factors.

Abstract:Objectives To investigate the impact of the first time plateau experience on soldiers' cognitive function. Methods The computer neuropsychological tests were carried out on 20 soldiers who stationed and trained at 4 500 m above the sea level for the first time（ acute plateau group） and 20 soldiers who stationed at 200 m above the sea level（ low-altitude group）. The tests included language memory， visual memory， finger tapping， symbolic digital coding， Stroop test， displacement attention test and continuous performance test. Based on correct responses， error responses， the number of responses and reaction time， the computer generates indicators that reflect military cognitive functions and can be used for statistical analysis， such as complex memory， speech memory， visual memory， psychomotor speed， reaction time， complex attention， cognitive flexibility， processing speed， executive function， simple attention， fine motor speed， and overall neurocognitive index. Results Compared with the low-altitude group， the scores of all neurocognitive fields in the acute plateau group were significantly reduced， and the overall neurocognitive index， complex memory， speech memory， psychomotor speed， reaction time， processing speed， and executive function were statistically different（ P＜0.05）. The overall neurocognitive index， reaction time， processing speed， executive function and positive oxygen saturation were positively correlated. Conclusions The exposure to acute highaltitude hypobaric hypoxia can lower a few aspects of neuropsychological performance， which is equivalent to the impaired cognitive function caused by mild brain injury.

Abstract:Objectives To analyze the relationship between the location of acute single cerebral infarction（ ASCI） and secondary restless leg syndrome（ SRLS）. Methods The data of 556 continuous patients with ASCI were collected retrospectively， including demographic characteristics， laboratory results， imaging data， coexisting diseases， clinical characteristics of ASCI. All the patients were divided into SRLS group and non-SRLS group. Comparing between the two groups， univariate analysis was used to explore the related factors of SRLS in patients with ASCI， and multivariate analysis was used to explore the independent related factors of SRLS in patients with ASCI. Results Of the 556 ASCI patients included， 26（ 4.68%） suffered SRLS. Univariate analysis revealed uric acid was associated with the morbidity of SRLS（ P＜0.05）， and the incidence of SRLS was higher in thalamic and pons ASCI patients. Multivariate analysis revealed that ASCI occurring in the location of thalamus（ OR=5.81，P＜ 0.05） and pons（ OR=2.65， P＜ 0.05） are independent predictors for SRLS. Conclusions In patients with ASCI， the location of infarction is associated with the morbidity of SRLS， and ASCI occurring in the thalamus and pons may be independent predictors for SRLS.

Abstract:Objectives To explore the effect of robot-assisted gait training（ RAGT） on the gait ability in patients with hemiplegia after stroke. Methods From January 2015 to October 2016， a total of 60 patients with hemiplegia were randomly divided into the RAGT group（ n=30） and control group（ n=30）. Both groups received conventional rehabilitation， while the RAGT group was given robot-assisted gait training and control group was given manually assisted gait training 30 minutes a day， 5 days a week for 8 weeks. L-FORCE/HIP/ Flex（ FHF）， 6-minutes walking distance（ 6MWD）， maximum walking speed（ MWS） and Fugl-Meyer Assessment of legs（ FMA-LE） were evaluated before and after training. Results There was no significant difference in general information and indexes between the two groups before training（ P ＞ 0.05）. The scores improved in both groups after training（ P＜0.05）. The FHF， 6MWD， MWS， and FMA-LE of RAGT group was（ 51.53±22.24）Nm， （80.50±15.62）m，（ 45.54±29.49）s and（ 21.81±7.77）， respectively， which were significantly better than the control group［ （43.65±24.94）Nm，（ 66.44±19.81）m，（ 58.89±21.76）s and（ 15.13±8.67）， P＜0.05］. Conclusions Robot-assisted gait training can effectively improve the gait ability of stroke patients with hemiplegia.

Abstract:Objectives To investigate the possible role of interleukin-33（ IL-33） in cognitive impairment caused by hypoperfusion of the carotid artery. Methods A total of 36 adult male Sprague-Dawley （SD） rats were randomly divided into 3 groups： sham operation（ S） group， Lesion 2 weeks（ L2w） group， and Lesion 4 weeks（ L4w） group. The Morris water maze was used to test the learning and memory ability of each group. The expression of cleaved-caspase-3 in the hippocampus was tested by immunohistochemistry. The expression of IL-33 in the hippocampus was tested by Western-blot method. Results The differences in the water maze test performance and the expression of cleaved-caspase-3 and IL-33 were statistically significant between the three groups（ F=64.201，P＜0.05；F=233.558，P＜0.05；F=51.498，P＜0.05）. Compared with the S group（ 20.32±6.30）s， the escape latency of the L2w group（ 46.67±9.49） s was significantly prolonged （t=-4.902，P ＜ 0.05）； compared with the L2w group， the escape latency of the L4w group（ 81.51±14.67）s was significantly prolonged（ t=-6.397，P＜ 0.05）. Compared with the S group（ 1.31±1.19）， the expression of cleaved-caspase-3 in the hippocampus in the L2w group（ 6.56±1.32） was significantly increased（ t=-6.328， P＜0.05）； compared with the L2w group， the L4w group's（ 18.78±5.83） expression of cleaved-caspase-3 in the hippocampus was significantly increased（ t=-14.733，P＜0.05）. Compared with the S group（ 0.26±0.02）， the expression of IL-33 in hippocampus in the L2w group（ 0.3±0.04） increased， but the results were not statistically significant（ t=-1.530，P=0.147）； compared with the L2w group， the L4w group's expression of IL-33 in the hippocampus（ 0.49±0.06） was significantly increased（ t=-7.924，P＜0.05）. Conclusions IL-33 may play a role in cognitive impairment caused by hypoperfusion of brain tissue.

Abstract:Objective To explore the clinical effect of computer-assisted cognitive training on language function and cognitive ability improvement of patients with aphasia after traumatic brain injury （TBI）. Methods A total of 80 patients with TBI with aphasia were selected as subjects from January 2013 to December 2017， and divided into trial group and control group by random number table method. The two groups were given conventional treatment and language therapy. Additionally， computer-assisted training was performed in the trial group at the same time. All the subjects were evaluated with Loewenstein Occupational Therapy Cognitive Assessment Battery（ LOTCA） and Clinical Rehabilitation Research Center Aphasia Examination （CR-RCAE） for their cognitive and language function after 2 months. Results After intervention， the LOTCA scores of orientation， perception， vision and thinking of the two groups were significantly improved， and the CR-RCAE scores of repetition， expression， reading aloud and naming were significantly improved， and the trial group was better than the control group， with statistical significance（ P＜0.05）. Conclusions Computerassisted cognitive training has enhancement effect on language function and cognitive ability improvement in patients with aphasia after TBI.

Abstract:Objectives To test the reliability and validity of the Chinese version of the Social Impact Scale（ SIS） for the stigma of stroke patients in China， and to provide an effective tool for assessing the stigma of stroke patients. Methods A total of 170 stroke patients who met the inclusion criteria were selected by the Rehabilitation Medicine Department of a tertiary hospital in Xi'an， Shaanxi Province. The Chinese version SIS was used to investigate the stigma. Using the degree of discrimination， coefficient of variation， and correlation analysis to analyze the scale items， Cronbach's alpha， content validity index， and exploratory factor analysis were used to evaluate the reliability， content validity， structural validity of the scale. The criterion-related validity is used to measure the correlation between social impact scale and daily activity ability， self-esteem， and depression. Results A total of 170 questionnaires were distributed， and 164 valid questionnaires were returned. The response rate was 96.5%. The SIS can identify high and low groups（ P＜0.01）， the coefficient of variation of each item of the scale is over 15%， and the correlation coefficient between each dimension and total score of the scale is 0.739-0.875（ P＜ 0.01）. The correlation coefficient between the score and the total score of the scale is 0.325-0.738（ P＜0.01）. The results of the exploratory factor analysis retain 18 items， and one common factor is extracted for each dimension. The contribution of each common factor to variance is more than 45%. Finally， each dimension contained no less than three items， and the factor load is ＞ 0.60. The content validity index of each item of the scale is 0.875-1.000， and the content validity index of the scale is 0.944. The revised social impact scale consists of 4 dimensions and 18 items. The internal consistency of the total scale Cronbach's α coefficient is 0.908， and the Cronbach's α coefficients of each dimension are 0.711， 0.662， 0.840， 0.777， respectively. The correlation coefficient of each item is 0.457-0.783（ P＜0.01）. The correlation coefficient of each dimension is 0.449-0.867（ P＜0.01）. The revised SIS score was negatively correlated with daily activity ability and self-esteem score（ r=-0.238， -0.309， P ＜ 0.01）， and positively correlated with depression score（ r=0.537， P＜0.01）. Conclusions The revised SIS has ideal reliability and validity and can be used to evaluate the stigma in stroke patients in China.

Abstract:Objectives To observe the short-term and long-term curative effect in the treatment of trigeminal neuralgia by nerve trunk injection for nerve damage treatment with mixture composed of adriamycin and anhydrous ethanol. Methods A total of 91 cases with trigeminal neuralgia patients were treated for nerve damage by transcutaneous puncture and injecting mixture composed of adriamycin and anhydrous ethanol into trigeminal nerve trunk. Pain visual analogue score（ VAS） and pain relief level were recorded at the time points of prior treatment， the treatment day and 7 days， 1 month， 3 months， 6 months， 1 year and 2 years after operation. Results The pain recurrence rate of 91 patients within one year was 5.49%（ 5/91）. VAS score after treatment was significantly lower than that before the treatment at each time point and lower than that on the treatment day （P ＜ 0.01）. The differences were all no statistical significance in VAS score by pairwise comparison between 3 months， 6 months， 1 year and 2 years after treatment（ P ＞ 0.05）. The significant efficiency was 49.45%， 83.52%， 95.60%， 94.51%， 96.55%， 93.02% and 86.57% respectively on the treatment day， and 7 days， 1 month， 3 months， 6 months， 1 year， 2 years after treatment（ P＜0.05）. The mean rank of pain relief level at 7 days，1 month，3 months， 6 months， 1 year and 2 years after treatment were significantly lower than that on the treatment day（ P ＜0.05）. The mean rank of each time point at 1 month， 3 months， 6 months， 1 year and 2 years after treatment was significantly lower than that at 7 days after treatment（ P ＜ 0.01）. There was no statistical significance in the mean rank in pain relief level of 1 month， 3 months， 6 months， 1 year and 2 years after treatment by pairwise comparison（ P ＞ 0.05）. No serious complications occurred in all patients. Conclusions The treatment of trigeminal neuralgia by nerve trunk injection for nerve damage treatment with mixture composed of adriamycin and anhydrous ethanol is easy to operate and has no serious complications with good short-term and long-term effects.

Abstract:Atherosclerosis is one of the most essential causes of ischemic vascular disease， while inflammation and cell death play an important role during its development. Pyroptosis is a programmed proinflammatory cell death proess. Recent studies have shown that the pyroptosis of endothelial cells， macrophages and smooth muscle cells accelerates the progress of atherosclerosis. Therefore，It may provide us a new method for the prevention and treatment of atherosclerosis-related diseasesa to have a better understanding of pyroptosis. This article aims at reviewing the relationship between pyroptosis and atherosclerosis.

Abstract:Alcohol is an addictive substance， and alcohol abuse and dependence has become a serious social and medical problem on a global scale. Due to many factors such as drinking culture and alcohol accessibility in China， the problem of alcohol use disorder in China is becoming increasingly prominent. Treatment of such diseases is very important. The treatment of alcohol use disorders mainly includes drug and non-drug treatment. This article will review the new progress on drug treatment