Abstract:Violent and aggressive behaviors in schizophrenia has become one of the problems affecting society and public health. Studies have shown that the violent crime rate of schizophrenia patients is 4-7 times higher than that of the general population. Biological factors such as genetics， neurobiochemistry and metabolism play important roles in the violent and aggressive behaviors of patients with schizophrenia. Therefore， it is of great significance to study the biological mechanism of violence and aggressive behavior in schizophrenia. This review focuses on the biological research progress of violence and aggressive behavior in schizophrenia.

Abstract:Objective To observe the expression of osteopontin （OPN） in patients with hypertensive intracerebral hemorrhage （HICH） and its relationship with the brain edema， neurological impairment and clinical prognosis. Methods A total of 17 patients with HICH admitted to the medical intensive care unit of Neurology Department of Linyi People's Hospital were collected as observation group. The hematoma fluid was extracted through stereotactic soft-channel intracranial hematoma evacuation， and the peripheral blood was extracted simultaneously. The amount of hematoma and edema in the observation group were measured， and

Abstract:Objective To explore the factors associated with free medication compliance in communitybased patients with severe mental disorders at home in Huairou District of Beijing. Methods A total of 600 patients with severe mental disorders who were registered in the Beijing Huairou Mental Health Management System from March 2018 to March 2019 were selected by simple random sampling method， and investigated by Morisky Adherence Questionnaire （MAQ-8）. According to the results of the survey， patients were divided into poor compliance group （MAQ-8 score less than 6） and good compliance gourp （MAQ-8 score between 6 and 8）. The general characteristics （gender， age， working condition， living environment， marital status， living style， physical disease， family history， history of drug allergy， disease type， family income， education attainment， hospitalization times， etc.） and the factors influencing medication compliance were collected. 15 patients with severe mental disorders were interviewed， and the data were analyzed by phenomenological analysis. 9 themes affecting medication compliance were identified. T-test and Chi-square test were used to analyze the differences of general characteristics between the poor compliance group and the good compliance group. Multivariate logistic regression analysis was used to analyze the factors influencing the compliance. Results In this study， a total of 600 cases were screened and 435 cases of effective information were collected， among which 325 cases （74.7%） had good medication compliance and 110 cases （25.3%） had poor medication compliance. Among the reasons for not taking prescribed medication， the highest choice rate was forgetting to take medicine （60.0%， 66/110）， followed by lack of supervision （43.6%， 48/110） and lack of insight of the disease （35.5%，39/110）. Multivariate logistic regression analysis showed that the medication compliance of patients living in plain area was worse than that of patients living in mountainous area （OR=2.41， 95%CI：1.14-5.10，P ＜ 0.05）； the medication compliance of patients with monthly family income less than 3000 yuan was better than that of patients with monthly family income more than 5 000 yuan （OR=0.36，95%CI： 0.19-0.70，P ＜ 0.01）； low education level was a risk factor for medication compliance （OR=13.81，95%CI：2.82-67.7，P ＜ 0.01）. Conclusions Among the patients with severe mental disorders taking free medication in the community in Huairou District of Beijing， living environment， monthly household income， and education attainment are the main influencing factors of compliance. The reasons for not taking medication as prescribed include forgetting to take medication for various reasons， not taking medication without supervision of a guardian and lack of insight.

Abstract:Objective To analyze the influencing factors of different length of hospitalization in patients with schizophrenia. Methods Cluster sampling was used to review the electronic medical record system for schizophrenia inpatients admitted to Wuxi Mental Health Center from January 1 to December 31 in 2018. Basic and clinical data were collected， including gender， age， job， household registration， guardian， payment method for hospitalization， diagnostic classification， comorbidities， length of hospitalization. Disordered multinomial logistic regression was used to analyze the influencing factors of the different length of hospitalization. Results A total of 1 063 inpatients were investigated， with average age （49.97±15.58） years， male （566， 53.25%）， unemployment （943， 88.71%）， urban registered permanent residence （916， 86.17%）， course of disease more than 5 years （809， 76.11%）， number of hospitalizations more than 3 times （594， 55.87%）， paranoid schizophrenia （619， 58.23%）， comorbid somatic disease （590， 55.5%）， and medical insurance payment （895，84.2%）. 20.79% of the subjects were hospitalized for less than 1 month （221 cases）more than 1 month and less than 3 months accounted for 34.34% （365 cases）； more than 3 months and less than 12 months accounted for 11.00% （117 cases）； at least 12 months accounted for 33.87% （360 cases）. Regression analysis showed that male （OR=1.913， 95%CI：1.326-2.759；OR=2.835， 95%CI：1.717-4.679； OR=4.341， 95%CI：2.782-6.772）， unemployment （OR=1.735， 95%CI：1.082-2.780； OR=5.988， 95%CI：2.376- 15.087； OR=3.960， 95%CI：1.901-8.248）， medical insurance payment （OR=2.747， 95%CI：1.820-4.145； OR=7.565， 95%CI：3.502-16.342； OR=14.531， 95%CI：6.430-32.839） were the common influencing factors of hospitalization length more than 1 and less than 3 months， more than 3 months and less than 12 months， and at least 12 months. Non-core caregivers （OR=2.087， 95%CI：1.178-3.696； OR=4.173， 95%CI：2.539-6.856）， and more than 3 times of hospitalization （OR=1.775， 95%CI：1.095-2.878； OR=4.272， 95%CI：2.748- 6.641） were important risk factors for hospitalization length more than 3 months. Age more than 50 years old （OR=2.290， 95%CI：1.407-3.729）， course of disease more than 5 years （OR=5.555， 95%CI：2.749-11.228）， comorbid somatic disease （OR=2.034， 95%CI：1.301-3.181） were independent risk factors for hospitalization duration at least 12 months. Conclusions The length of hospitalization of schizophrenic patients are generally longer. Male， unemployment， medical insurance payment， non-core caregivers， hospitalization times more than 3 times， course of disease more than 5 years， age more than or equal to 50 years old， and comorbid somatic disease are closely related to the length of hospitalization and long-term hospitalization.

Abstract:Objective To evaluate the effects of computerized-assisted cognitive remediation therapy on patients with schizophrenia. Methods Randomized controlled trials （RCT） on computerized-assisted cognitive remediation therapy in the rehabilitation of patients with schizophrenia were searched for from databases such as PubMed， Web of Science， Cochrane Library， China academic journal full text database， VIP China Science and technology journal database， Wanfang Data medical journal database and other resources， with a time limit from establishment of the database to September 2020. Data were analyzed with RevMan 5.3 software. Results A total of 18 RCTs were included. The results of meta-analysis showed that computerized-assisted cognitive remediation therapy significantly relieved the symptoms ［positive symptoms： 95%CI（-2.34- -0.03），P=0.04； negative symptoms： 95%CI（-2.98--1.97），P ＜ 0.01； general psychotic symptoms： 95%CI （-2.07--1.25），P＜ 0.01； overall symptoms： 95%CI（-6.59--0.86），P=0.01］， also improved quality of life and social function ［quality of life： 95%CI（0.15-1.35），P=0.01； social function： 95%CI（0.20-1.37），P=0.009］. However， the results of enhancing interpersonal relationship and working ability were not statistically significant ［interpersonal relationship： 95%CI（-0.25-0.81），P=0.30； working ability： 95%CI（-0.62-0.18）， P=0.28］. Conclusions Computerized-assisted cognitive remediation therapy has positive effects on relieving the psychiatric symptoms， improving the quality of life， and enhancing social functions on patients with schizophrenia， but the effects on interpersonal relationships and working ability still need further study.

Abstract:Schizophrenia is a common， unexplained， and serious mental disease which often involves a lifetime with high prevalence rate， high recurrence rate and high disability rate. Patients with recurrent schizophrenia have severe repercussions， including cognitive dysfunction， impaired social function， and quality of life decline. Recent researches on related factors of schizophrenia relapse are relatively scattered. This article reviews the definition and related factors of schizophrenia relapse.

Abstract:Circular RNA （circRNA）， a new class of endogenous closed non-coding RNA， which has been discovered in recent years and can be used as microRNA adsorption sponge， RNA-binding protein， transcription regulators and other ways to regulate the expression of target genes. It plays an important role in cell proliferation， migration， apoptosis， aging and other biological processes. CircRNA is highly expressed in the nervous system and cardiovascular system， and is widely involved in the occurrence and development of agerelated diseases through various mechanisms. Recent studies have shown that circRNA plays a key role in agerelated diseases such as Alzheimer disease， Parkinson disease and atherosclerosis. This article reviews the role and mechanism of circRNA in neurodegenerative diseases and atherosclerosis.

Abstract:Depressive disorder is a serious medical， public and economic problem because of its unknown etiology and limitation of drug treatment. Epigenetic regulation plays an important role both in neural development and psychiatric disorders. In recent years many stress animal models identified abnormal expression of some histone deacetylases in particular brain regions which lead to depression-like behaviors. Histone deacetylase inhibitors， as a kind of epigenetic regulatory drugs， can regulate gene transcription， thus have antidepressant effect. This paper reviews the research progress of histone deacetylase and its inhibitors in depressive disorder and provides a wider range of options for the treatment of depressive disorder.

Abstract:Acute ischemic stroke is one of the major diseases which endanger the lives and health of people in China. Inflammatory reaction is closely associated with acute cerebral infarction， and the level of inflammatory markers reflects the severity of inflammation. Especially MLR （monocyte to lymphocyte ratio） and NLR （Neutrophil to lymphocyte ratio） in peripheral blood， as emerging indicators of inflammation in recent years， have been widely concerned. This article reviews the correlation between MLR and NLR in peripheral blood， and the occurrence， progression and prognosis of acute cerebral infarction.

Abstract:As one of the most common forms of stroke， acute ischemic stroke is currently treated by reperfusion， including intravenous thrombolytic therapy and intravascular therapy. Intravenous thrombolysis within 6 hours after the onset of acute ischemic stroke can improve the prognosis. However， intravenous thrombolysis also has the risk of hemorrhagic transformation， which may adversely affect the early improvement of neurological function and long-term prognosis of patients. Current studies suggest that inflammatory reaction is mainly involved in the physiological and pathological mechanism of hemorrhagic transformation after intravenous thrombolysis in patients with acute ischemic stroke. In this paper， the risk predictors of the correlation between inflammatory response and hemorrhagic transformation after intravenous thrombolysis are reviewed in order to provide evidence for the early identification and prevention of hemorrhagic transformation after intravenous thrombolysis.

Abstract:Bipolar disorder （BD） is a group of highly heterogeneous diseases， mostly occurring in early adulthood， but the pathological mechanism is still unclear. In recent years， there is evidence to support the hypothesis that "neurodevelopmental abnormality" may be involved in the pathogenesis of some BD patients， especially those with early-onset psychotic symptoms， providing a new direction for the study of its pathological mechanism. This paper reviews the evidence from perinatal risk factors， early clinical features， neuropsychology， brain imaging and genome.

Abstract:Balint group is an intervention to improve the relationship between doctors and patients， which can improve the communication ability of medical staff and improve job burnout. This paper introduces the origin and development， research status at home and abroad， action mechanism， and activity process of Balint group， and summarizes the problems existing in the application of Balint group in medical staff and puts forward some suggestions. The prospect of the applications of Balint group in more fields in China is prospected， in order to provide the direction for follow-up research work.